Script Choices

So I'm working on my script. I dunno... It seems a little generic. I play a quick game of spot the cliché and pick up on a few. The next question I ask myself is "are these really clichés or just things common to the environment my script is set in?". The question after that was "does it matter?". I then decided this entire line of questioning (myself) didn't really matter anyway.

So this is what I've got...

1. An angry character who is dissatisfied with their job because they don't see the point.
2. A shy character who is the target of unwanted romantic advances from their manager.
3. A creepy manager disliked by the first two.
4. Colleagues who don't want to help either of the first two.

I need to decide what gender each of these characters is going to be. Should I go with the obvious (man, woman, man) clichéd cast? Should I try and reverse the clichés (woman, man, woman)? How would it change if every character was male? What if they were all female? Is it a cliché to have a manager as an antagonist? Would basic plot (#1 and #2 discover weird secret and disrupt the office to escape their jobs) work if the manager is a friend instead of a villain? Is portraying the manager as a monster/villain fair? Is there a way to turn the story around at the end and have the two main characters success be the cause of a catastrophe? Would this remove any redeeming features from the two "good" characters? Would this end up turning the manager into a sort-of anti-hero?